Excessive Daytime Sleepiness in Major Dementia Syndromes

Angelica Boeve, Tanis J. Ferman, Jeremiah Aakre, Erik St. Louis, Michael Silber, Mary Machulda, Julie Fields, Neill Graff-Radford, Michelle Mielke, Yonas Geda, David Jones, Jonathon Graff-Radford, David Knopman, Ronald Petersen, Brad Boeve

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer’s disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P <.05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81% vs bvFTD 47% vs AD 45%, P <.01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalAmerican Journal of Alzheimer's Disease and Other Dementias
Issue number4
StatePublished - Jun 1 2019
Externally publishedYes


  • Alzheimer’s disease
  • dementia with Lewy bodies
  • excessive daytime sleepiness
  • frontotemporal dementia

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


Dive into the research topics of 'Excessive Daytime Sleepiness in Major Dementia Syndromes'. Together they form a unique fingerprint.

Cite this