@inproceedings{02564a4b58194266b1727dcd9b3404ca,
title = "Evaluation of anti-cancer drug Suberoylanilide Hydroxamic Acid (SAHA) on cancer cell phenotype in a three-dimensional (3D) breast tumor-stroma platform",
abstract = "We report a microfluidic platform with distinct tumor and stromal regions for preclinical anticancer drug evaluation. Highly metastatic SUM159 breast cancer cells were encapsulated in 3D matrix and injected into the tumor region of the microfluidic platform. The cells adopted an invasive morphology and proliferated profusely, migrating from the tumor compartment to the stromal region. Addition of FDA-approved histone deacetylase inhibitor (HDACi) Suberoylanilide Hydroxamic Acid (SAHA) into the cell media substantially inhibited migration of cancer cells, inducing morphological changes such as elongation and increased protrusions. The proposed platform enables studies on anticancer drug interactions within a physiologically relevant tumor-stroma microenvironment.",
keywords = "Chemotherapeutic, Microfluidic, Tumor microenvironment, Vorinostat (SAHA)",
author = "N. Peela and D. Truong and Barrientos, {E. S.} and G. Mouneimne and Mehdi Nikkhah",
note = "Funding Information: The authors would like to acknowledge National Science Foundation (NSF) Award no 1510700.; 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",
year = "2016",
language = "English (US)",
series = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
publisher = "Chemical and Biological Microsystems Society",
pages = "565--566",
booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
}