Estimating the number of granule cells in the dentate gyrus with the disector

Mark J. West, Paul D. Coleman, Dorothy G. Flood

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


A practical example is given of how a newly developed stereological estimator of particle number, the disector, can be used to make estimates of neuron number in the dentate gyrus of rats. The estimates are free of biases related to lost caps, overprojection and assumptions about size, shape and orientation of the objects that are counted. The disector principle and the practical considerations relating to histological preparations and sampling are presented.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalBrain Research
Issue number1
StatePublished - May 10 1988
Externally publishedYes


  • Dentate gyrus
  • Disector
  • Granule cell
  • Morphometrics
  • Stereology

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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