TY - JOUR
T1 - Estimating Ethnic Admixture from Pedigree Data
AU - Sinsheimer, Janet S.
AU - Plaisier, Christopher L.
AU - Huertas-Vazquez, Adriana
AU - Aguilar-Salinas, Carlos
AU - Tusie-Luna, Teresa
AU - Pajukanta, Päivi
AU - Lange, Kenneth
N1 - Funding Information:
The authors thank the families for the participation. They also thank Laura Riba and Maribel Rodriguez for recruiting these families, collecting the samples, and maintaining the pedigree database. The research was supported in part by United States Public Health Service grants MH59490, GM53275, T32-HG002536, HL082762, HL-28481, and HL-70150, as well as by American Heart Association grant 0430180N.
PY - 2008/3/3
Y1 - 2008/3/3
N2 - This paper introduces a likelihood method of estimating ethnic admixture that uses individuals, pedigrees, or a combination of individuals and pedigrees. For each founder of a pedigree, admixture proportions are calculated by conditioning on the pedigree-wide genotypes at all ancestry-informative markers. These estimates are then propagated down the pedigree to the nonfounders by a simple averaging process. The large-sample standard errors of the founders' proportions can be similarly transformed into standard errors for the admixture proportions of the descendants. These standard errors are smaller than the corresponding standard errors when each individual is treated independently. Both hard and soft information on a founder's ancestry can be accommodated in this scheme, which has been implemented in the genetic software package Mendel. The utility of the method is demonstrated on simulated data and a real data example involving Mexican families of mixed Amerindian and Spanish ancestry.
AB - This paper introduces a likelihood method of estimating ethnic admixture that uses individuals, pedigrees, or a combination of individuals and pedigrees. For each founder of a pedigree, admixture proportions are calculated by conditioning on the pedigree-wide genotypes at all ancestry-informative markers. These estimates are then propagated down the pedigree to the nonfounders by a simple averaging process. The large-sample standard errors of the founders' proportions can be similarly transformed into standard errors for the admixture proportions of the descendants. These standard errors are smaller than the corresponding standard errors when each individual is treated independently. Both hard and soft information on a founder's ancestry can be accommodated in this scheme, which has been implemented in the genetic software package Mendel. The utility of the method is demonstrated on simulated data and a real data example involving Mexican families of mixed Amerindian and Spanish ancestry.
UR - http://www.scopus.com/inward/record.url?scp=41149113412&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41149113412&partnerID=8YFLogxK
U2 - 10.1016/j.ajhg.2007.12.014
DO - 10.1016/j.ajhg.2007.12.014
M3 - Article
C2 - 18319077
AN - SCOPUS:41149113412
SN - 0002-9297
VL - 82
SP - 748
EP - 755
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 3
ER -