@inbook{3bec4c823f5742349adbdda7f90fce1b,
title = "Engineering transport systems for microbial production",
abstract = "The rapid development in the field of metabolic engineering has enabled complex modifications of metabolic pathways to generate a diverse product portfolio. Manipulating substrate uptake and product export is an important research area in metabolic engineering. Optimization of transport systems has the potential to enhance microbial production of renewable fuels and chemicals. This chapter comprehensively reviews the transport systems critical for microbial production as well as current genetic engineering strategies to improve transport functions and thus production metrics. In addition, this chapter highlights recent advancements in engineering microbial efflux systems to enhance cellular tolerance to industrially relevant chemical stress. Lastly, future directions to address current technological gaps are discussed.",
keywords = "Efflux pumps, Metabolic engineering, Microbial production, Product export, Transporters",
author = "Moses Onyeabor and Rodrigo Martinez and Gavin Kurgan and Xuan Wang",
note = "Funding Information: We thank members of the Xuan Wang and David Nielsen laboratories at Arizona State University for helpful discussions. Rodrigo Martinez was supported by WAESO-LSAMP Bridge to Doctorate Fellowship. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
doi = "10.1016/bs.aambs.2020.01.002",
language = "English (US)",
series = "Advances in Applied Microbiology",
publisher = "Academic Press Inc",
pages = "33--87",
booktitle = "Advances in Applied Microbiology",
}