Engineering sugar utilization and microbial tolerance toward lignocellulose conversion

Lizbeth M. Nieves, Larry A. Panyon, Xuan Wang

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


Production of fuels and chemicals through a fermentation-based manufacturing process that uses renewable feedstock such as lignocellulosic biomass is a desirable alternative to petrochemicals. Although it is still in its infancy, synthetic biology offers great potential to overcome the challenges associated with lignocellulose conversion. In this review, we will summarize the identification and optimization of synthetic biological parts used to enhance the utilization of lignocellulose-derived sugars and to increase the biocatalyst tolerance for lignocellulose-derived fermentation inhibitors. We will also discuss the ongoing efforts and future applications of synthetic integrated biological systems used to improve lignocellulose conversion.

Original languageEnglish (US)
Article number00017
JournalFrontiers in Bioengineering and Biotechnology
Issue numberFEB
StatePublished - 2015


  • Furan aldehydes
  • Lignocellulose
  • Metabolic engineering
  • Synthetic biology
  • Xylose

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Histology
  • Biomedical Engineering


Dive into the research topics of 'Engineering sugar utilization and microbial tolerance toward lignocellulose conversion'. Together they form a unique fingerprint.

Cite this