TY - JOUR
T1 - Engineering microbes with synthetic biology frameworks
AU - Leonard, Effendi
AU - Nielsen, David
AU - Solomon, Kevin
AU - Prather, Kristala Jones
N1 - Funding Information:
This work was supported by the Synthetic Biology Engineering Research Center (SynBERC) funded by the National Science Foundation (Grant Number 0540879), and the MIT Energy Initiative (Grant Number 6917278).
PY - 2008/12
Y1 - 2008/12
N2 - Typically, the outcome of biologically engineered unit operations cannot be controlled a priori due to the incorporation of ad hoc design into complex natural systems. To mitigate this problem, synthetic biology presents a systematic approach to standardizing biological components for the purpose of increasing their programmability and robustness when assembled with the aim to achieve novel biological functions. A complex engineered biological system using only standardized biological components is yet to exist. Nevertheless, current attempts to create and to implement modular, standardized biological components pave the way for the future creation of highly predictable artificial biological systems. Although synthetic biology frameworks can be applied to any biological engineering endeavor, this article will focus on providing a brief overview of advances in the field and its recent utilization for the engineering of microbes.
AB - Typically, the outcome of biologically engineered unit operations cannot be controlled a priori due to the incorporation of ad hoc design into complex natural systems. To mitigate this problem, synthetic biology presents a systematic approach to standardizing biological components for the purpose of increasing their programmability and robustness when assembled with the aim to achieve novel biological functions. A complex engineered biological system using only standardized biological components is yet to exist. Nevertheless, current attempts to create and to implement modular, standardized biological components pave the way for the future creation of highly predictable artificial biological systems. Although synthetic biology frameworks can be applied to any biological engineering endeavor, this article will focus on providing a brief overview of advances in the field and its recent utilization for the engineering of microbes.
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U2 - 10.1016/j.tibtech.2008.08.003
DO - 10.1016/j.tibtech.2008.08.003
M3 - Review article
C2 - 18977048
AN - SCOPUS:55649091668
SN - 0167-7799
VL - 26
SP - 674
EP - 681
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 12
ER -