Engineering bacterial sugar catabolism and tolerance toward lignocellulose conversion

Andrew D. Flores, Gavin L. Kurgan, Xuan Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Lignocellulosic biomass represents a renewable domestic feedstock that can support large-scale biochemical production processes for fuels and specialty chemicals. However, cost-effective conversion of lignocellulosic sugars into valuable chemicals still remains a challenge. Biomass recalcitrance to saccharification, microbial sugar co-utilization and toxic chemicals associated with chemical pretreatments are at the center of the bottlenecks limiting further commercialization of lignocellulose conversion. Genetic and metabolic engineering has allowed researchers to manipulate microorganisms to overcome these challenges. In this chapter, a broad overview of the current knowledge and research efforts in two paramount areas is presented: (1) bacterial carbon catabolite repression and sugar co-utilization, and (2) microbial tolerance to inhibitors derived from lignocellulose pretreatments. Lastly, technological gaps and future directions for further improvements are discussed. This chapter will mainly focus on the relevant knowledge and research progress from the perspective of bacterial strain engineering.

Original languageEnglish (US)
Title of host publicationEngineering of Microorganisms for the Production of Chemicals and Biofuels from Renewable Resources
PublisherSpringer International Publishing
Number of pages34
ISBN (Electronic)9783319517292
ISBN (Print)9783319517285
StatePublished - Jan 1 2017


  • Alternative feedstock
  • Carbon catabolite repression
  • Furan aldehydes
  • Lignocellulose conversion
  • Metabolic engineering
  • Sugar catabolism

ASJC Scopus subject areas

  • General Medicine
  • General Health Professions
  • General Biochemistry, Genetics and Molecular Biology


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