Abstract
An emerging area of regenerative medicine is the engineering of artificial extracellular matrices that recapitulate biochemical and biophysical characteristics of native tissue environments to create an instructive microenvironment through a variety of biomaterials-based approaches. Key components of an artificial niche comprise a combination of biophysical, biochemical, and intercellular signaling. This microenvironment can be used for in vitro studies or to recapitulate an in vivo setting, to study cellular processes in a controlled manner or replace tissue. This article outlines details on fundamental and state of the art strategies in engineering artificial niches for regenerative medicine applications.
| Original language | English (US) |
|---|---|
| Title of host publication | Encyclopedia of Tissue Engineering and Regenerative Medicine |
| Subtitle of host publication | Volumes 1-3 |
| Publisher | Elsevier |
| Pages | V1-103-V1-108 |
| Volume | 1-3 |
| ISBN (Electronic) | 9780128137000 |
| ISBN (Print) | 9780128136997 |
| DOIs | |
| State | Published - Jan 1 2019 |
| Externally published | Yes |
Keywords
- Artificial niche
- Biochemical cues
- Biomaterials
- Biophysical cues
- Cellular interactions
- Matrices
- Microenvironment
- Regenerative medicine
- Tissue engineering
- Topographical features
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology