Encapsulation of gold nanoparticles in a DNA origami cage

Zhao Zhao, Erica L. Jacovetty, Yan Liu, Hao Yan

Research output: Contribution to journalArticlepeer-review

127 Scopus citations


Fold and label: A critical challenge in nanoparticle (NP) surface functionalization is to label the NP surface with a single copy of a functional group or to display multiple, unique molecules on the NP surface with control of the orientation and intermolecular distance. This challenge was addressed with the construction of a spatially addressable, self-assembling DNA origami nanocage that encapsulates gold nanoparticles and interrupts its surface symmetry (see scheme).

Original languageEnglish (US)
Pages (from-to)2041-2044
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number9
StatePublished - Feb 25 2011


  • DNA
  • gold
  • nanoparticles
  • nanotechnology

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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