TY - JOUR
T1 - Effect of albendazole in experimental toxocariasis of mice
AU - Delgado, O.
AU - Botto, C.
AU - Mattei, R.
AU - Escalante, A.
PY - 1989
Y1 - 1989
N2 - Fifty-five mice were each infected with 800 embryonated eggs of Toxocara canis. Beginning on the second day of the infection, one group received a single 9 mg dose of albendazole every 24 hours for an eight day period while a second group received 3 mg of albendazole every eight hours for the same period.On the tenth day of infection, mice in each treatment group and their corresponding controls were sacrificed, and the prescence and motility of T. canis larvae in the brain were determined. With both therapeutical procedures the administration of albendazole reduced the number of larvae which reach the brain. However, for the same total dose the administration of the drug every eight hours yielded results which were significantly superior to those produced by administering a single dose every 24 hours, reducing both the number of larvae in the brain and their motility
AB - Fifty-five mice were each infected with 800 embryonated eggs of Toxocara canis. Beginning on the second day of the infection, one group received a single 9 mg dose of albendazole every 24 hours for an eight day period while a second group received 3 mg of albendazole every eight hours for the same period.On the tenth day of infection, mice in each treatment group and their corresponding controls were sacrificed, and the prescence and motility of T. canis larvae in the brain were determined. With both therapeutical procedures the administration of albendazole reduced the number of larvae which reach the brain. However, for the same total dose the administration of the drug every eight hours yielded results which were significantly superior to those produced by administering a single dose every 24 hours, reducing both the number of larvae in the brain and their motility
UR - http://www.scopus.com/inward/record.url?scp=0024834301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024834301&partnerID=8YFLogxK
U2 - 10.1080/00034983.1989.11812396
DO - 10.1080/00034983.1989.11812396
M3 - Article
C2 - 2619377
AN - SCOPUS:0024834301
SN - 0003-4983
VL - 83
SP - 621
EP - 624
JO - Annals of Tropical Medicine and Parasitology
JF - Annals of Tropical Medicine and Parasitology
IS - 6
ER -