Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11

Robert B. Bates, Kennard G. Brusoe, Jennifer J. Burns, Sriyani Caldera, Wei Cui, Sanjeev Gangwar, Michelle R. Gramme, Kelly J. McClure, Gregory P. Rouen, Heiko Schadow, Chad C. Stessman, Stuart R. Taylor, Vicky H. Vu, Gayle V. Yarick, Jianxing Zhang, George R. Pettit, Roger Bontems

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


The first synthesis of dolastatin 11, a potent antineoplastic agent from the sea hare Dolabella auricularia, confirmed the proposed structure and established the last configuration in this natural product and in dolastatin 12, majusculamide C, and 57-normajusculamide C.

Original languageEnglish (US)
Pages (from-to)2111-2113
Number of pages3
JournalJournal of the American Chemical Society
Issue number9
StatePublished - 1997

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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