TY - JOUR
T1 - Do antinuclear antibodies in primary biliary cirrhosis patients identify increased risk for liver failure?
AU - Yang, Wei Hong
AU - Yu, Jiang Hong
AU - Nakajima, Ayako
AU - Neuberg, Donna
AU - Lindor, Keith
AU - Bloch, Donald B.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2004/12
Y1 - 2004/12
N2 - Background & Aims:: Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease with a variable clinical course. Identification of serologic markers associated with increased risk of liver failure would assist in management of PBC patients. The objective of this study was to identify antinuclear antibody (ANA) markers that may be used to predict PBC outcome. Methods: Indirect immunofluorescence was used to identify ANAs in 492 PBC patients. χ 2 and Kaplan-Meier analyses were used to examine the association between ANAs and liver failure. Results: A greater percentage of ANA-positive, compared to ANA-negative, PBC patients developed liver failure (41% vs 25%, P =. 005). The presence of anti-centromere antibodies was associated with liver failure (anti-centromere antibody positive vs negative, 58% vs 33%, P =. 001). The time to liver failure was shorter in ANA-positive, compared with ANA-negative, patients (log rank score 5.8, P =. 02). After 8.9 years (the median follow-up for patients without liver failure), 68% of ANA-positive and 81% of ANA-negative patients were free of liver failure. Anti-centromere antibodies were also associated with a shorter time to liver failure (log rank score 8.4, P =. 004). After 8.9 years, 52% of anti-centromere antibody positive and 74% of anti-centromere antibody negative patients were without liver failure. Conclusions: ANAs in general, and anti-centromere antibodies in particular, are associated with liver failure in PBC. PBC patients with ANAs may be candidates for treatment with experimental therapies to prolong the interval between diagnosis and liver failure. ANA-negative patients, who appear to have a relatively benign clinical course, should perhaps be treated with ursodeoxycholic acid alone.
AB - Background & Aims:: Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease with a variable clinical course. Identification of serologic markers associated with increased risk of liver failure would assist in management of PBC patients. The objective of this study was to identify antinuclear antibody (ANA) markers that may be used to predict PBC outcome. Methods: Indirect immunofluorescence was used to identify ANAs in 492 PBC patients. χ 2 and Kaplan-Meier analyses were used to examine the association between ANAs and liver failure. Results: A greater percentage of ANA-positive, compared to ANA-negative, PBC patients developed liver failure (41% vs 25%, P =. 005). The presence of anti-centromere antibodies was associated with liver failure (anti-centromere antibody positive vs negative, 58% vs 33%, P =. 001). The time to liver failure was shorter in ANA-positive, compared with ANA-negative, patients (log rank score 5.8, P =. 02). After 8.9 years (the median follow-up for patients without liver failure), 68% of ANA-positive and 81% of ANA-negative patients were free of liver failure. Anti-centromere antibodies were also associated with a shorter time to liver failure (log rank score 8.4, P =. 004). After 8.9 years, 52% of anti-centromere antibody positive and 74% of anti-centromere antibody negative patients were without liver failure. Conclusions: ANAs in general, and anti-centromere antibodies in particular, are associated with liver failure in PBC. PBC patients with ANAs may be candidates for treatment with experimental therapies to prolong the interval between diagnosis and liver failure. ANA-negative patients, who appear to have a relatively benign clinical course, should perhaps be treated with ursodeoxycholic acid alone.
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U2 - 10.1016/S1542-3565(04)00465-3
DO - 10.1016/S1542-3565(04)00465-3
M3 - Article
C2 - 15625657
AN - SCOPUS:11144330639
SN - 1542-3565
VL - 2
SP - 1116
EP - 1122
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 12
ER -