DNA topoisomerase I inhibitors from Rinorea anguifera

Ji Ma, Shannon H. Jones, Rebekah Marshall, Xihan Wu, Sidney M. Hecht

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


An organic extract prepared from Rinorea anguifera was investigated in order to identify the natural principle(s) responsible for stabilization of a topoisomerase I-DNA covalent binary complex. Bioassay-guided fractionation resulted in the isolation of mauritianin and (+)-syringaresinol as new topoisomerase I inhibitors, and also of the known inhibitor camptothecin.

Original languageEnglish (US)
Pages (from-to)813-816
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number3
StatePublished - Feb 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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