DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems

Shenliang Wang; Jia Guo; Toshikazu Ono; Eric T. Kool

doi:10.1002/anie.201201928

DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems

Shenliang Wang, Jia Guo, Toshikazu Ono, Eric T. Kool

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Dye-ing to live: Spectral limitations of common organic dyes make it difficult or impossible to visualize and follow multiple biological components in rapidly moving systems. The development of a multispectral set of improved DNA-scaffolded fluorophores is described. Their use in multicolor cellular imaging (see scheme) and in tracking of biological motions on the subsecond timescale is demonstrated.

Original language	English (US)
Pages (from-to)	7176-7180
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	29
DOIs	https://doi.org/10.1002/anie.201201928
State	Published - Jul 16 2012
Externally published	Yes

Keywords

Fluorescence
Imaging agents
Multicolor
Oligonucleotides
Real-time tracking

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201201928

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abstract = "Dye-ing to live: Spectral limitations of common organic dyes make it difficult or impossible to visualize and follow multiple biological components in rapidly moving systems. The development of a multispectral set of improved DNA-scaffolded fluorophores is described. Their use in multicolor cellular imaging (see scheme) and in tracking of biological motions on the subsecond timescale is demonstrated.",

keywords = "Fluorescence, Imaging agents, Multicolor, Oligonucleotides, Real-time tracking",

author = "Shenliang Wang and Jia Guo and Toshikazu Ono and Kool, {Eric T.}",

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AU - Wang, Shenliang

AU - Guo, Jia

AU - Ono, Toshikazu

AU - Kool, Eric T.

PY - 2012/7/16

Y1 - 2012/7/16

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AB - Dye-ing to live: Spectral limitations of common organic dyes make it difficult or impossible to visualize and follow multiple biological components in rapidly moving systems. The development of a multispectral set of improved DNA-scaffolded fluorophores is described. Their use in multicolor cellular imaging (see scheme) and in tracking of biological motions on the subsecond timescale is demonstrated.

KW - Fluorescence

KW - Imaging agents

KW - Multicolor

KW - Oligonucleotides

KW - Real-time tracking

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JF - Angewandte Chemie - International Edition

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ER -

DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems

Abstract

Keywords

ASJC Scopus subject areas

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