TY - JOUR
T1 - DNA nanostructures as models for evaluating the role of enthalpy and entropy in polyvalent binding
AU - Nangreave, Jeanette
AU - Yan, Hao
AU - Liu, Yan
PY - 2011/3/30
Y1 - 2011/3/30
N2 - DNA nanotechnology allows the design and construction of nanoscale objects that have finely tuned dimensions, orientation, and structure with remarkable ease and convenience. Synthetic DNA nanostructures can be precisely engineered to model a variety of molecules and systems, providing the opportunity to probe very subtle biophysical phenomena. In this study, several such synthetic DNA nanostructures were designed to serve as models to study the binding behavior of polyvalent molecules and gain insight into how small changes to the ligand/receptor scaffolds, intended to vary their conformational flexibility, will affect their association equilibrium. This approach has yielded a quantitative identification of the roles of enthalpy and entropy in the affinity of polyvalent DNA nanostructure interactions, which exhibit an intriguing compensating effect.
AB - DNA nanotechnology allows the design and construction of nanoscale objects that have finely tuned dimensions, orientation, and structure with remarkable ease and convenience. Synthetic DNA nanostructures can be precisely engineered to model a variety of molecules and systems, providing the opportunity to probe very subtle biophysical phenomena. In this study, several such synthetic DNA nanostructures were designed to serve as models to study the binding behavior of polyvalent molecules and gain insight into how small changes to the ligand/receptor scaffolds, intended to vary their conformational flexibility, will affect their association equilibrium. This approach has yielded a quantitative identification of the roles of enthalpy and entropy in the affinity of polyvalent DNA nanostructure interactions, which exhibit an intriguing compensating effect.
UR - http://www.scopus.com/inward/record.url?scp=79953041320&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953041320&partnerID=8YFLogxK
U2 - 10.1021/ja1103298
DO - 10.1021/ja1103298
M3 - Article
C2 - 21381740
AN - SCOPUS:79953041320
SN - 0002-7863
VL - 133
SP - 4490
EP - 4497
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 12
ER -