DNA Kirigami Driven by Polymerase-Triggered Strand Displacement

Kuiting Chen, Fei Xu, Yingxin Hu, Hao Yan, Linqiang Pan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The precursors of functional biomolecules in living cells are synthesized in a bottom-up manner and subsequently activated by modification into a delicate structure with near-atomic precision. DNA origami technology provides a promising way to mimic the synthesis of precursors, although mimicking the modification process is a challenge. Herein, a DNA paper-cutting (DNA kirigami) method to trim origami into designer nanostructures is proposed, where the modification is implemented by a polymerase-triggered DNA strand displacement reaction. Six geometric shapes are created by cutting rectangular DNA origami. Gel electrophoresis and atomic force microscopy results demonstrate the feasibility and capability of the DNA paper-cutting method. The proposed DNA paper-cutting strategy can enrich the toolbox for dynamically transforming DNA origami and has potential applications in biomimetics.

Original languageEnglish (US)
Article number2201478
Issue number24
StatePublished - Jun 16 2022


  • biomimetics
  • DNA origami
  • dynamic DNA origami
  • polymerase-triggered strand displacement

ASJC Scopus subject areas

  • Biotechnology
  • Chemistry(all)
  • Biomaterials
  • Materials Science(all)


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