Abstract
A survey of crude plant extracts using a new yeast strain designed to identify DNA-damaging agents resulted in the identification of an extract prepared from Crypteronia paniculata. Bioassay-guided fractionation resulted in the isolation of three active compounds. Two of these were ellagic acid derivatives, namely, 3,3′-di-O-methylellagic acid 4′-O-β-D-xylopyranoside (1) and 3′-O-methyl-3,4-methylenedioxyellagic acid 4′-O-β-D-glucopyranoside (2). The third was identified as kaempferol-3-O-α-L-rhamnoside (3). The three principles exhibited strong, selective cytotoxity toward the RAD52 repair-deficient yeast strain.
Original language | English (US) |
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Pages (from-to) | 1930-1932 |
Number of pages | 3 |
Journal | Journal of Natural Products |
Volume | 65 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry