TY - JOUR
T1 - Discovery of novel fish papillomaviruses
T2 - From the Antarctic to the commercial fish market
AU - Kraberger, Simona
AU - Austin, Charlotte
AU - Farkas, Kata
AU - Desvignes, Thomas
AU - Postlethwait, John H.
AU - Fontenele, Rafaela S.
AU - Schmidlin, Kara
AU - Bradley, Russell W.
AU - Warzybok, Pete
AU - Van Doorslaer, Koenraad
AU - Davison, William
AU - Buck, Christopher B.
AU - Varsani, Arvind
N1 - Funding Information:
The authors are grateful to Alison McBride, and Karl Munger for their advice on papillomavirus oncogenes. The field work in the Ross Sea was supported by a grant (K057) awarded to WD from Antarctica New Zealand . The field work on the West Antarctic Peninsula was supported by the National Science Foundation ( NSF ) polar program grant OPP-1543383 (JHP, TD). The molecular work described in this study for the fish from Ross Sea was supported by the Center of Evolution and Medicine Venture Fund (Center of Evolution and Medicine, Arizona State University, USA ) grant awarded to AV. The molecular data acquisition on fish from the West Antarctic Peninsula was supported by the NSF polar grant OPP-1947040 (awarded to TD, AV and JHP). In addition, the NSF polar grant OPP-1947040 also partially supported SK, TD, JHP, RSF and AV. The commercial market fish work was funded in part by the NIH Intramural Research Program, with support from the NCI Center for Cancer Research awarded to CB. The collection of cloacal swabs from Western gulls was conducted by Point Blue Conservation Science with the support of the California Academy of Sciences and the U.S. Fish and Wildlife Service under cooperative agreement number 81640-5-J046 .
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2022/1/2
Y1 - 2022/1/2
N2 - Fish papillomaviruses form a newly discovered group broadly recognized as the Secondpapillomavirinae subfamily. This study expands the documented genomes of the fish papillomaviruses from six to 16, including one from the Antarctic emerald notothen, seven from commercial market fishes, one from data mining of sea bream sequence data, and one from a western gull cloacal swab that is likely diet derived. The genomes of secondpapillomaviruses are ∼6 kilobasepairs (kb), which is substantially smaller than the ∼8 kb of terrestrial vertebrate papillomaviruses. Each genome encodes a clear homolog of the four canonical papillomavirus genes, E1, E2, L1, and L2. In addition, we identified open reading frames (ORFs) with short linear peptide motifs reminiscent of E6/E7 oncoproteins. Fish papillomaviruses are extremely diverse and phylogenetically distant from other papillomaviruses suggesting a model in which terrestrial vertebrate-infecting papillomaviruses arose after an evolutionary bottleneck event, possibly during the water-to-land transition.
AB - Fish papillomaviruses form a newly discovered group broadly recognized as the Secondpapillomavirinae subfamily. This study expands the documented genomes of the fish papillomaviruses from six to 16, including one from the Antarctic emerald notothen, seven from commercial market fishes, one from data mining of sea bream sequence data, and one from a western gull cloacal swab that is likely diet derived. The genomes of secondpapillomaviruses are ∼6 kilobasepairs (kb), which is substantially smaller than the ∼8 kb of terrestrial vertebrate papillomaviruses. Each genome encodes a clear homolog of the four canonical papillomavirus genes, E1, E2, L1, and L2. In addition, we identified open reading frames (ORFs) with short linear peptide motifs reminiscent of E6/E7 oncoproteins. Fish papillomaviruses are extremely diverse and phylogenetically distant from other papillomaviruses suggesting a model in which terrestrial vertebrate-infecting papillomaviruses arose after an evolutionary bottleneck event, possibly during the water-to-land transition.
KW - Centropristis striata
KW - Larus occidentalis
KW - Melanogrammus aeglefinus
KW - Papillomavirus
KW - Sparus aurata
KW - Trematomus bernacchii
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U2 - 10.1016/j.virol.2021.10.007
DO - 10.1016/j.virol.2021.10.007
M3 - Article
C2 - 34739918
AN - SCOPUS:85118511929
SN - 0042-6822
VL - 565
SP - 65
EP - 72
JO - Virology
JF - Virology
ER -