Diffractive imaging of single particles

John C.H. Spence

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


The computational methods and applications of diffractive diffractive imaging (lensless) lensless imagingimaginglensless imaging are reviewed. Far-field scattering (e.g., by neutrons, electrons, light, or x-rays) by a nonperiodic localized potential is detected and the phase problem solved using iterative optimization methods, which allows a three-dimensional image of the object potential to be reconstructed without the need for a lens. The history of the subject and its relationship to the crystallographic phase problem are reviewed, together with a summary of theory, algorithms, uniqueness issues, resolution limits, the constraint ratio concept, and coherence requirements. Applications, from various forms of microscopy (electron, optical, and x-ray) to snapshot x-ray laser single-particle imaging, are reviewed. The method of ptychography, which achieves a similar aim, is reviewed elsewhere in these volumes.

Original languageEnglish (US)
Title of host publicationSpringer Handbooks
Number of pages28
StatePublished - 2019

Publication series

NameSpringer Handbooks
ISSN (Print)2522-8692
ISSN (Electronic)2522-8706

ASJC Scopus subject areas

  • General


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