@inproceedings{8a48222b01484d7f8aad11740fe84262,
title = "Differentiating the biomechanics of normal and diseased cells using isotropically etched silicon microstructures and atomic force microscopy",
abstract = "This paper reports studying the differential biomechanical properties of HS68 normal human fibroblast cells and MDA-MB-231 human breast cancer cell (as the key cell types in tumour microenvironment [1]) using MEMS-based three dimensional (3-D) silicon microstructures and Atomic Force Microscopy (AFM). AFM results indicates that the cancer cells have significantly softer cytoskeletal structure (E=0.51±0.35 kPa) compared to normal fibroblast cells (E=1.86±1.13 kPa) supporting our previous observations and explaining the differential adhesion of normal and diseased cells to different compartments of the 3-D silicon microstructures.",
keywords = "AFM, Breast cancer, Isotropic microchambers, MEMS, Silicon",
author = "Mehdi Nikkhah and Strobl, {Jeannine S.} and Masoud Agah",
year = "2009",
language = "English (US)",
isbn = "9780979806421",
series = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "1805--1807",
booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
note = "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 ; Conference date: 01-11-2009 Through 05-11-2009",
}