TY - JOUR
T1 - Differential effect of an Ig μ transgene on development of pre-B cells in fetal and adult SCID mice
AU - Bosma, Gayle C.
AU - Chang, Yung
AU - Karasuyama, Hajime
AU - Bosma, Melvin J.
PY - 1999/10/12
Y1 - 1999/10/12
N2 - Progression of pro-B lymphocytes to the pre-B stage depends on the expression of a pre-B cell receptor (pre-BCR), consisting of an Ig μ H chain, Ig surrogate light chain, and associated signal transducing chains. Mice that are unable to express a pre-BCR show an arrest of B cell development at the pro-B stage. Such is the case for severe combined immune deficient (SCID) mice in which μ chains are not made because of a defect in V(D)J recombination. When μ chains are made, as in SCID mice bearing a functional transgene, then B cell differentiation can proceed to the pre-B stage. However, as reported here, a μ transgene (M54) that promotes development of SCID pre-B cells in adult bone marrow fails to do so in fetal liver. We suggest that a pre-BCR containing the M54 μ chain cannot signal progression of pro-B cells to the pre-B stage in the fetal liver microenvironment.
AB - Progression of pro-B lymphocytes to the pre-B stage depends on the expression of a pre-B cell receptor (pre-BCR), consisting of an Ig μ H chain, Ig surrogate light chain, and associated signal transducing chains. Mice that are unable to express a pre-BCR show an arrest of B cell development at the pro-B stage. Such is the case for severe combined immune deficient (SCID) mice in which μ chains are not made because of a defect in V(D)J recombination. When μ chains are made, as in SCID mice bearing a functional transgene, then B cell differentiation can proceed to the pre-B stage. However, as reported here, a μ transgene (M54) that promotes development of SCID pre-B cells in adult bone marrow fails to do so in fetal liver. We suggest that a pre-BCR containing the M54 μ chain cannot signal progression of pro-B cells to the pre-B stage in the fetal liver microenvironment.
KW - B cell differentiation
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U2 - 10.1073/pnas.96.21.11952
DO - 10.1073/pnas.96.21.11952
M3 - Article
C2 - 10518557
AN - SCOPUS:0032692935
SN - 0027-8424
VL - 96
SP - 11952
EP - 11957
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 21
ER -