Depression history, stress, and pain in rheumatoid arthritis patients

Alex J. Zautra, Brendt P. Parrish, Christina M. Van Puymbroeck, Howard Tennen, Mary Davis, John W. Reich, Mike Irwin

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


This study examined the role of past episodes of depression on pain reports for patients with rheumatoid arthritis (RA) before and during stress induction. A history of major depressive episodes was assessed by diagnostic interviews for 138 RA patients, 74 who later participated in a set of laboratory procedures designed to induce interpersonal stress. Patients were evaluated by a rheumatologist and then asked to report joint and bodily pain throughout the laboratory study. We found that RA patients with a history of two or more episodes of major depression had more pain at baseline, and exhibited higher pain in response to the stress induction than did RA patients with either only one episode or no history of depression. Such findings provide new insight in the dynamic relationships between depression, stress, and pain.

Original languageEnglish (US)
Pages (from-to)187-197
Number of pages11
JournalJournal of Behavioral Medicine
Issue number3
StatePublished - Jun 2007


  • Depression history
  • Pain
  • Rheumatoid arthritis
  • Stress

ASJC Scopus subject areas

  • Psychology(all)
  • Psychiatry and Mental health


Dive into the research topics of 'Depression history, stress, and pain in rheumatoid arthritis patients'. Together they form a unique fingerprint.

Cite this