Denisovan DNA in Late Pleistocene sediments from Baishiya Karst Cave on the Tibetan Plateau

Dongju Zhang; Huan Xia; Fahu Chen; Bo Li; Viviane Slon; Ting Cheng; Ruowei Yang; Zenobia Jacobs; Qingyan Dai; Diyendo Massilani; Xuke Shen; Jian Wang; Xiaotian Feng; Peng Cao; Melinda A. Yang; Juanting Yao; Jishuai Yang; David B. Madsen; Yuanyuan Han; Wanjing Ping; Feng Liu; Charles Perreault; Xiaoshan Chen; Matthias Meyer; Janet Kelso; Svante Pääbo; Qiaomei Fu

doi:10.1126/SCIENCE.ABB6320

Denisovan DNA in Late Pleistocene sediments from Baishiya Karst Cave on the Tibetan Plateau

Dongju Zhang, Huan Xia, Fahu Chen, Bo Li, Viviane Slon, Ting Cheng, Ruowei Yang, Zenobia Jacobs, Qingyan Dai, Diyendo Massilani, Xuke Shen, Jian Wang, Xiaotian Feng, Peng Cao, Melinda A. Yang, Juanting Yao, Jishuai Yang, David B. Madsen, Yuanyuan Han, Wanjing PingFeng Liu, Charles Perreault, Xiaoshan Chen, Matthias Meyer, Janet Kelso, Svante Pääbo, Qiaomei Fu

Human Evolution and Social Change, School of (SHESC)

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

A late Middle Pleistocene mandible from Baishiya Karst Cave (BKC) on the Tibetan Plateau has been inferred to be from a Denisovan, an Asian hominin related to Neanderthals, on the basis of an amino acid substitution in its collagen. Here we describe the stratigraphy, chronology, and mitochondrial DNA extracted from the sediments in BKC. We recover Denisovan mitochondrial DNA from sediments deposited ~100 thousand and ~60 thousand years ago (ka) and possibly as recently as ~45 ka. The long-term occupation of BKC by Denisovans suggests that they may have adapted to life at high altitudes and may have contributed such adaptations to modern humans on the Tibetan Plateau.

Original language	English (US)
Pages (from-to)	584-587
Number of pages	4
Journal	Science
Volume	370
Issue number	6516
DOIs	https://doi.org/10.1126/SCIENCE.ABB6320
State	Published - Oct 30 2020

ASJC Scopus subject areas

General

Access to Document

10.1126/SCIENCE.ABB6320

Cite this

Zhang, D., Xia, H., Chen, F., Li, B., Slon, V., Cheng, T., Yang, R., Jacobs, Z., Dai, Q., Massilani, D., Shen, X., Wang, J., Feng, X., Cao, P., Yang, M. A., Yao, J., Yang, J., Madsen, D. B., Han, Y., ... Fu, Q. (2020). Denisovan DNA in Late Pleistocene sediments from Baishiya Karst Cave on the Tibetan Plateau. Science, 370(6516), 584-587. https://doi.org/10.1126/SCIENCE.ABB6320

Zhang, D, Xia, H, Chen, F, Li, B, Slon, V, Cheng, T, Yang, R, Jacobs, Z, Dai, Q, Massilani, D, Shen, X, Wang, J, Feng, X, Cao, P, Yang, MA, Yao, J, Yang, J, Madsen, DB, Han, Y, Ping, W, Liu, F, Perreault, C, Chen, X, Meyer, M, Kelso, J, Pääbo, S & Fu, Q 2020, 'Denisovan DNA in Late Pleistocene sediments from Baishiya Karst Cave on the Tibetan Plateau', Science, vol. 370, no. 6516, pp. 584-587. https://doi.org/10.1126/SCIENCE.ABB6320

@article{470ae48627ba476fb9dd8c9ab279a6d6,

title = "Denisovan DNA in Late Pleistocene sediments from Baishiya Karst Cave on the Tibetan Plateau",

abstract = "A late Middle Pleistocene mandible from Baishiya Karst Cave (BKC) on the Tibetan Plateau has been inferred to be from a Denisovan, an Asian hominin related to Neanderthals, on the basis of an amino acid substitution in its collagen. Here we describe the stratigraphy, chronology, and mitochondrial DNA extracted from the sediments in BKC. We recover Denisovan mitochondrial DNA from sediments deposited ~100 thousand and ~60 thousand years ago (ka) and possibly as recently as ~45 ka. The long-term occupation of BKC by Denisovans suggests that they may have adapted to life at high altitudes and may have contributed such adaptations to modern humans on the Tibetan Plateau.",

author = "Dongju Zhang and Huan Xia and Fahu Chen and Bo Li and Viviane Slon and Ting Cheng and Ruowei Yang and Zenobia Jacobs and Qingyan Dai and Diyendo Massilani and Xuke Shen and Jian Wang and Xiaotian Feng and Peng Cao and Yang, {Melinda A.} and Juanting Yao and Jishuai Yang and Madsen, {David B.} and Yuanyuan Han and Wanjing Ping and Feng Liu and Charles Perreault and Xiaoshan Chen and Matthias Meyer and Janet Kelso and Svante P{\"a}{\"a}bo and Qiaomei Fu",

year = "2020",

month = oct,

day = "30",

doi = "10.1126/SCIENCE.ABB6320",

language = "English (US)",

volume = "370",

pages = "584--587",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6516",

}

TY - JOUR

T1 - Denisovan DNA in Late Pleistocene sediments from Baishiya Karst Cave on the Tibetan Plateau

AU - Zhang, Dongju

AU - Xia, Huan

AU - Chen, Fahu

AU - Li, Bo

AU - Slon, Viviane

AU - Cheng, Ting

AU - Yang, Ruowei

AU - Jacobs, Zenobia

AU - Dai, Qingyan

AU - Massilani, Diyendo

AU - Shen, Xuke

AU - Wang, Jian

AU - Feng, Xiaotian

AU - Cao, Peng

AU - Yang, Melinda A.

AU - Yao, Juanting

AU - Yang, Jishuai

AU - Madsen, David B.

AU - Han, Yuanyuan

AU - Ping, Wanjing

AU - Liu, Feng

AU - Perreault, Charles

AU - Chen, Xiaoshan

AU - Meyer, Matthias

AU - Kelso, Janet

AU - Pääbo, Svante

AU - Fu, Qiaomei

PY - 2020/10/30

Y1 - 2020/10/30

N2 - A late Middle Pleistocene mandible from Baishiya Karst Cave (BKC) on the Tibetan Plateau has been inferred to be from a Denisovan, an Asian hominin related to Neanderthals, on the basis of an amino acid substitution in its collagen. Here we describe the stratigraphy, chronology, and mitochondrial DNA extracted from the sediments in BKC. We recover Denisovan mitochondrial DNA from sediments deposited ~100 thousand and ~60 thousand years ago (ka) and possibly as recently as ~45 ka. The long-term occupation of BKC by Denisovans suggests that they may have adapted to life at high altitudes and may have contributed such adaptations to modern humans on the Tibetan Plateau.

AB - A late Middle Pleistocene mandible from Baishiya Karst Cave (BKC) on the Tibetan Plateau has been inferred to be from a Denisovan, an Asian hominin related to Neanderthals, on the basis of an amino acid substitution in its collagen. Here we describe the stratigraphy, chronology, and mitochondrial DNA extracted from the sediments in BKC. We recover Denisovan mitochondrial DNA from sediments deposited ~100 thousand and ~60 thousand years ago (ka) and possibly as recently as ~45 ka. The long-term occupation of BKC by Denisovans suggests that they may have adapted to life at high altitudes and may have contributed such adaptations to modern humans on the Tibetan Plateau.

UR - http://www.scopus.com/inward/record.url?scp=85091940344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85091940344&partnerID=8YFLogxK

U2 - 10.1126/SCIENCE.ABB6320

DO - 10.1126/SCIENCE.ABB6320

M3 - Article

C2 - 33122381

AN - SCOPUS:85091940344

SN - 0036-8075

VL - 370

SP - 584

EP - 587

JO - Science

JF - Science

IS - 6516

ER -

Denisovan DNA in Late Pleistocene sediments from Baishiya Karst Cave on the Tibetan Plateau

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this