Demethylation of 7-methylguanosine with lithium 2-methylpropane-2-thiolate

Sidney M. Hecht, John W. Kozarich

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


7-Methylguanosine, a component of transfer ribonucleic acid, is demethylated to guanosine, its presumed biochemical precursor, by a powerful new nucleophilic reagent, lithium 2-methylpropane-2-thiolate in hexamethylphosphoramide.

Original languageEnglish (US)
Pages (from-to)387-388
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number12
StatePublished - Jan 1 1973
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine


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