TY - JOUR
T1 - Deformation Mechanisms of "two-Part" Natural Adhesive in Bone Interfibrillar Nano-Interfaces
AU - Morsali, Reza
AU - Dai, Zhengwei
AU - Wang, Yang
AU - Qian, Dong
AU - Minary-Jolandan, Majid
N1 - Funding Information:
This work was supported by the grant from the US National Science Foundation (award CMMI-1727960), the US Air Force Office of Scientific Research (FA9550-14-1-0252), and the National Natural Science Foundation of China (grant no. 51303065). The authors appreciate the discussion of the research with Dr. Zhong Zhou.
Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/11/11
Y1 - 2019/11/11
N2 - Noncollagenous proteins at nanoscale interfaces in bone are less than 2-3% of bone content by weight, while they contribute more than 30% to fracture toughness. Major gaps in quantitative understanding of noncollagenous proteins' role in the interfibrillar interfaces, largely because of the limitation of probing their nanoscale dimension, have resulted in ongoing controversies and several outstanding hypotheses on their role and function, arguably going back to centuries ago to the original work from Galileo. Our results from the first detailed computational model of the nano-interface in the bone reveal "synergistic" deformation mechanism of a "double-part" natural glue, that is, noncollagenous osteopontin and osteocalcin at the interfibrillar interface. Specifically, through strong anchoring and formation of dynamic binding sites on mineral nanoplatelets, the nano-interface can sustain a large nonlinear deformation with ductility approaching 5000%. This large deformation results in an outstanding specific energy to failure exceeding ∼350 J/g, which is larger than the most known tough materials (such as Kevlar, spider silk, and so forth.).
AB - Noncollagenous proteins at nanoscale interfaces in bone are less than 2-3% of bone content by weight, while they contribute more than 30% to fracture toughness. Major gaps in quantitative understanding of noncollagenous proteins' role in the interfibrillar interfaces, largely because of the limitation of probing their nanoscale dimension, have resulted in ongoing controversies and several outstanding hypotheses on their role and function, arguably going back to centuries ago to the original work from Galileo. Our results from the first detailed computational model of the nano-interface in the bone reveal "synergistic" deformation mechanism of a "double-part" natural glue, that is, noncollagenous osteopontin and osteocalcin at the interfibrillar interface. Specifically, through strong anchoring and formation of dynamic binding sites on mineral nanoplatelets, the nano-interface can sustain a large nonlinear deformation with ductility approaching 5000%. This large deformation results in an outstanding specific energy to failure exceeding ∼350 J/g, which is larger than the most known tough materials (such as Kevlar, spider silk, and so forth.).
KW - bone protein interface
KW - bone toughness
KW - computational simulation
KW - energy dissipation
KW - nano-interface
KW - natural glue
KW - steered molecular dynamics
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U2 - 10.1021/acsbiomaterials.9b00588
DO - 10.1021/acsbiomaterials.9b00588
M3 - Article
C2 - 33405682
AN - SCOPUS:85073163485
SN - 2373-9878
VL - 5
SP - 5916
EP - 5924
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
IS - 11
ER -