Cytokine determinants of viral tropism

Grant McFadden, Mohamed R. Mohamed, Masmudur M. Rahman, Eric Bartee

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations


The specificity of a given virus for a cell type, tissue or species collectively known as viral tropism is an important factor in determining the outcome of viral infection in any particular host. Owing to the increased prevalence of zoonotic infections and the threat of emerging and re-emerging pathogens, gaining a better understanding of the factors that determine viral tropism has become particularly important. In this Review, we summarize our current understanding of the central role of antiviral and pro-inflammatory cytokines, particularly the interferons and tumour necrosis factor, in dictating viral tropism and how these cytokine pathways can be exploited therapeutically for cancer treatment and to better counter future threats from emerging zoonotic pathogens.

Original languageEnglish (US)
Pages (from-to)645-655
Number of pages11
JournalNature Reviews Immunology
Issue number9
StatePublished - Sep 2009
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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