TY - JOUR
T1 - Cyclotron production of 101mRh via proton-induced reactions on 103Rh targets
AU - Lagunas-Solar, Manuel C.
AU - Avila, Mario J.
AU - Johnson, Paul C.
N1 - Funding Information:
Acknowledgements-The authorsw ish to acknowledgtee ch-nicala ssistancfreo m Mr Neal J. Navarrod uringthe initial experimentaplh aseo f this project.W e also like to acknowledge the assistancefr om the Cyclotron Operationss taff during the target irradiations.T his project was partially fundedb y a U.S. Departmenot f Energy,r esearchc ontract No. DOE PA ER60056C ancerT herapy.
PY - 1984/8
Y1 - 1984/8
N2 - Targetry and a radiochemical process are reported for the production of no-carrier-added (NCA) 101mRh for use in the synthesis of radiopharmaceuticals. Proton-induced reactions on 103Rh targets were studied in order to evaluate the 103Rh(p,3n)101Pd→101mRh reaction as a source of high radionuclidic purity 101mRh. Cross sections (mb) and thin-target yields (mCi/μAh) for 101mRh, 101Rh, 100Rh, 101Pd, and 100Pd were measured at end-of-bombardment (EOB). The theoretical 101mRh cumulative yield from its 101Pd parent, at 32.7 h post EOB, was calculated as 4.71 ± 0.61 mCi/μAh, in the 67-to 15-MeV energy region. However, due to the production of the 20.8-h 100Rh, from its parent 3.63-d 100Pd, in the same energy region, a long decay time (> 170 h) is required to increase the radionuclidic purity of 101mRh to greater than 99%. The "effective" 101mRh yield is then reduced (to 1.0 mCi/μAh for a 4-h radiochemistry) due to decay losses. A radiochemical process used to prepare no-carrier-added (NCA) 101mRh is also explained, with emphasis on its effect on 101mRh yields.
AB - Targetry and a radiochemical process are reported for the production of no-carrier-added (NCA) 101mRh for use in the synthesis of radiopharmaceuticals. Proton-induced reactions on 103Rh targets were studied in order to evaluate the 103Rh(p,3n)101Pd→101mRh reaction as a source of high radionuclidic purity 101mRh. Cross sections (mb) and thin-target yields (mCi/μAh) for 101mRh, 101Rh, 100Rh, 101Pd, and 100Pd were measured at end-of-bombardment (EOB). The theoretical 101mRh cumulative yield from its 101Pd parent, at 32.7 h post EOB, was calculated as 4.71 ± 0.61 mCi/μAh, in the 67-to 15-MeV energy region. However, due to the production of the 20.8-h 100Rh, from its parent 3.63-d 100Pd, in the same energy region, a long decay time (> 170 h) is required to increase the radionuclidic purity of 101mRh to greater than 99%. The "effective" 101mRh yield is then reduced (to 1.0 mCi/μAh for a 4-h radiochemistry) due to decay losses. A radiochemical process used to prepare no-carrier-added (NCA) 101mRh is also explained, with emphasis on its effect on 101mRh yields.
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U2 - 10.1016/0020-708X(84)90080-2
DO - 10.1016/0020-708X(84)90080-2
M3 - Article
AN - SCOPUS:0021475350
SN - 0020-708X
VL - 35
SP - 743
EP - 748
JO - The International Journal Of Applied Radiation And Isotopes
JF - The International Journal Of Applied Radiation And Isotopes
IS - 8
ER -