Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ

Hyunjung Lim; Rajnish A. Gupta; Wen Ge Ma; Bibhash C. Paria; David E. Moller; Jason D. Morrow; Raymond N. DuBois; James M. Trzaskos; Sudhansu K. Dey

doi:10.1101/gad.13.12.1561

Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ

Hyunjung Lim, Rajnish A. Gupta, Wen Ge Ma, Bibhash C. Paria, David E. Moller, Jason D. Morrow, Raymond N. DuBois, James M. Trzaskos, Sudhansu K. Dey

Research output: Contribution to journal › Article › peer-review

543 Scopus citations

Abstract

We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate- limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI₂) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI₂ are mediated by its activation of the nuclear hormone receptor PPARδ, demonstrating the first reported biologic function of this receptor signaling pathway.

Original language	English (US)
Pages (from-to)	1561-1574
Number of pages	14
Journal	Genes and Development
Volume	13
Issue number	12
DOIs	https://doi.org/10.1101/gad.13.12.1561
State	Published - Jun 15 1999
Externally published	Yes

Keywords

COX2
Implantation
Mouse
PPARδ
Prostaglandins

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.13.12.1561

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title = "Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ",

abstract = "We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate- limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARδ, demonstrating the first reported biologic function of this receptor signaling pathway.",

keywords = "COX2, Implantation, Mouse, PPARδ, Prostaglandins",

author = "Hyunjung Lim and Gupta, {Rajnish A.} and Ma, {Wen Ge} and Paria, {Bibhash C.} and Moller, {David E.} and Morrow, {Jason D.} and DuBois, {Raymond N.} and Trzaskos, {James M.} and Dey, {Sudhansu K.}",

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doi = "10.1101/gad.13.12.1561",

language = "English (US)",

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T1 - Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ

AU - Lim, Hyunjung

AU - Gupta, Rajnish A.

AU - Ma, Wen Ge

AU - Paria, Bibhash C.

AU - Moller, David E.

AU - Morrow, Jason D.

AU - DuBois, Raymond N.

AU - Trzaskos, James M.

AU - Dey, Sudhansu K.

PY - 1999/6/15

Y1 - 1999/6/15

N2 - We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate- limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARδ, demonstrating the first reported biologic function of this receptor signaling pathway.

AB - We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate- limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARδ, demonstrating the first reported biologic function of this receptor signaling pathway.

KW - COX2

KW - Implantation

KW - Mouse

KW - PPARδ

KW - Prostaglandins

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Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ

Abstract

Keywords

ASJC Scopus subject areas

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