Cuboid Vesicles Formed by Frame-Guided Assembly on DNA Origami Scaffolds

Yuanchen Dong, Yuhe Renee Yang, Yiyang Zhang, Dianming Wang, Xixi Wei, Saswata Banerjee, Yan Liu, Zhongqiang Yang, Hao Yan, Dongsheng Liu

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


We describe the use of a frame-guided assembly (FGA) strategy to construct cuboid and dumbbell-shaped hetero-vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero-vesicle assemblies with complex DNA nano-scaffolds.

Original languageEnglish (US)
Pages (from-to)1586-1589
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number6
StatePublished - Feb 2017


  • DNA nanotechnology
  • amphiphiles
  • frame-guided assembly
  • self-assembly

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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