Cross-linked heterogeneous nanoparticles as bifunctional probe

Menghan Wang; Chao Wang; Kaylie L. Young; Liangliang Hao; Milica Medved; Tijana Rajh; H. Christopher Fry; Leyi Zhu; Gregory S. Karczmar; Cornelius Watson; J. Samuel Jiang; Nenad M. Markovic; Vojislav R. Stamenkovic

doi:10.1021/cm300381f

Cross-linked heterogeneous nanoparticles as bifunctional probe

Menghan Wang, Chao Wang, Kaylie L. Young, Liangliang Hao, Milica Medved, Tijana Rajh, H. Christopher Fry, Leyi Zhu, Gregory S. Karczmar, Cornelius Watson, J. Samuel Jiang, Nenad M. Markovic, Vojislav R. Stamenkovic

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A facile approach toward synthesis of multifunctional nanostructures through NP cross-linking was studied. Oleylamine-capped gold (Au) and iron oxide (Fe ₃O ₄) NPs, respectively, were obtained by reduction of chloroauric acid (HAuCl ₄) with oleylamine, and by reduction of iron acetylacetonate (Fe(acac) ₃) in a mixed solvent of benzyl ether and oleylamine. Thiol carboxylic polyethylene glycol molecule was used to crosslink Au and Fe ₃O ₄ NPs. NPs with HS-PEG-COOH resulted in large NP aggregates, most likely due to uncontrolled cross-linking that led to the formation of large NP networks. No large NP aggregates were observed, which was further validated by dynamic light scattering (DLS). These nanoparticle conjugates can be further linked with antibodies and drug molecules, thereby possessing great potential toward hierarchical diagnosis and treatment of disease.

Original language	English (US)
Pages (from-to)	2423-2425
Number of pages	3
Journal	Chemistry of Materials
Volume	24
Issue number	13
DOIs	https://doi.org/10.1021/cm300381f
State	Published - Jul 10 2012
Externally published	Yes

Keywords

bifunctional imaging
nanoparticle cross-linking
phase transfer
surface modification

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)
Materials Chemistry

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10.1021/cm300381f

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title = "Cross-linked heterogeneous nanoparticles as bifunctional probe",

abstract = "A facile approach toward synthesis of multifunctional nanostructures through NP cross-linking was studied. Oleylamine-capped gold (Au) and iron oxide (Fe 3O 4) NPs, respectively, were obtained by reduction of chloroauric acid (HAuCl 4) with oleylamine, and by reduction of iron acetylacetonate (Fe(acac) 3) in a mixed solvent of benzyl ether and oleylamine. Thiol carboxylic polyethylene glycol molecule was used to crosslink Au and Fe 3O 4 NPs. NPs with HS-PEG-COOH resulted in large NP aggregates, most likely due to uncontrolled cross-linking that led to the formation of large NP networks. No large NP aggregates were observed, which was further validated by dynamic light scattering (DLS). These nanoparticle conjugates can be further linked with antibodies and drug molecules, thereby possessing great potential toward hierarchical diagnosis and treatment of disease.",

keywords = "bifunctional imaging, nanoparticle cross-linking, phase transfer, surface modification",

author = "Menghan Wang and Chao Wang and Young, {Kaylie L.} and Liangliang Hao and Milica Medved and Tijana Rajh and Fry, {H. Christopher} and Leyi Zhu and Karczmar, {Gregory S.} and Cornelius Watson and Jiang, {J. Samuel} and Markovic, {Nenad M.} and Stamenkovic, {Vojislav R.}",

year = "2012",

month = jul,

day = "10",

doi = "10.1021/cm300381f",

language = "English (US)",

volume = "24",

pages = "2423--2425",

journal = "Chemistry of Materials",

issn = "0897-4756",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Cross-linked heterogeneous nanoparticles as bifunctional probe

AU - Wang, Menghan

AU - Wang, Chao

AU - Young, Kaylie L.

AU - Hao, Liangliang

AU - Medved, Milica

AU - Rajh, Tijana

AU - Fry, H. Christopher

AU - Zhu, Leyi

AU - Karczmar, Gregory S.

AU - Watson, Cornelius

AU - Jiang, J. Samuel

AU - Markovic, Nenad M.

AU - Stamenkovic, Vojislav R.

PY - 2012/7/10

Y1 - 2012/7/10

N2 - A facile approach toward synthesis of multifunctional nanostructures through NP cross-linking was studied. Oleylamine-capped gold (Au) and iron oxide (Fe 3O 4) NPs, respectively, were obtained by reduction of chloroauric acid (HAuCl 4) with oleylamine, and by reduction of iron acetylacetonate (Fe(acac) 3) in a mixed solvent of benzyl ether and oleylamine. Thiol carboxylic polyethylene glycol molecule was used to crosslink Au and Fe 3O 4 NPs. NPs with HS-PEG-COOH resulted in large NP aggregates, most likely due to uncontrolled cross-linking that led to the formation of large NP networks. No large NP aggregates were observed, which was further validated by dynamic light scattering (DLS). These nanoparticle conjugates can be further linked with antibodies and drug molecules, thereby possessing great potential toward hierarchical diagnosis and treatment of disease.

AB - A facile approach toward synthesis of multifunctional nanostructures through NP cross-linking was studied. Oleylamine-capped gold (Au) and iron oxide (Fe 3O 4) NPs, respectively, were obtained by reduction of chloroauric acid (HAuCl 4) with oleylamine, and by reduction of iron acetylacetonate (Fe(acac) 3) in a mixed solvent of benzyl ether and oleylamine. Thiol carboxylic polyethylene glycol molecule was used to crosslink Au and Fe 3O 4 NPs. NPs with HS-PEG-COOH resulted in large NP aggregates, most likely due to uncontrolled cross-linking that led to the formation of large NP networks. No large NP aggregates were observed, which was further validated by dynamic light scattering (DLS). These nanoparticle conjugates can be further linked with antibodies and drug molecules, thereby possessing great potential toward hierarchical diagnosis and treatment of disease.

KW - bifunctional imaging

KW - nanoparticle cross-linking

KW - phase transfer

KW - surface modification

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U2 - 10.1021/cm300381f

DO - 10.1021/cm300381f

M3 - Article

AN - SCOPUS:84863646782

SN - 0897-4756

VL - 24

SP - 2423

EP - 2425

JO - Chemistry of Materials

JF - Chemistry of Materials

IS - 13

ER -

Cross-linked heterogeneous nanoparticles as bifunctional probe

Abstract

Keywords

ASJC Scopus subject areas

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