Cross-linked heterogeneous nanoparticles as bifunctional probe

Menghan Wang, Chao Wang, Kaylie L. Young, Liangliang Hao, Milica Medved, Tijana Rajh, H. Christopher Fry, Leyi Zhu, Gregory S. Karczmar, Cornelius Watson, J. Samuel Jiang, Nenad M. Markovic, Vojislav R. Stamenkovic

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


A facile approach toward synthesis of multifunctional nanostructures through NP cross-linking was studied. Oleylamine-capped gold (Au) and iron oxide (Fe 3O 4) NPs, respectively, were obtained by reduction of chloroauric acid (HAuCl 4) with oleylamine, and by reduction of iron acetylacetonate (Fe(acac) 3) in a mixed solvent of benzyl ether and oleylamine. Thiol carboxylic polyethylene glycol molecule was used to crosslink Au and Fe 3O 4 NPs. NPs with HS-PEG-COOH resulted in large NP aggregates, most likely due to uncontrolled cross-linking that led to the formation of large NP networks. No large NP aggregates were observed, which was further validated by dynamic light scattering (DLS). These nanoparticle conjugates can be further linked with antibodies and drug molecules, thereby possessing great potential toward hierarchical diagnosis and treatment of disease.

Original languageEnglish (US)
Pages (from-to)2423-2425
Number of pages3
JournalChemistry of Materials
Issue number13
StatePublished - Jul 10 2012
Externally publishedYes


  • bifunctional imaging
  • nanoparticle cross-linking
  • phase transfer
  • surface modification

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry


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