Cranial thickness changes in early childhood

Niharika Gajawelli, Sean Deoni, Jie Shi, Holly Dirks, Marius George Linguraru, Marvin D. Nelson, Yalin Wang, Natasha Lepore

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


The neurocranium changes rapidly in early childhood to accommodate the developing brain. However, developmental disorders may cause abnormal growth of the neurocranium, the most common one being craniosynostosis, affecting about 1 in 2000 children. It is important to understand how the brain and neurocranium develop together to understand the role of the neurocranium in neurodevelopmental outcomes. However, the neurocranium is not as well studied as the human brain in early childhood, due to a lack of imaging data. CT is typically employed to investigate the cranium, but, due to ionizing radiation, may only be used for clinical cases. However, the neurocranium is also visible on magnetic resonance imaging (MRI). Here, we used a large dataset of MRI images from healthy children in the age range of 1 to 2 years old and extracted the neurocranium. A conformal geometry based analysis pipeline is implemented to determine a set of statistical atlases of the neurocranium. A growth model of the neurocranium will help us understand cranial bone and suture development with respect to the brain, which will in turn inform better treatment strategies for neurocranial disorders.

Original languageEnglish (US)
Title of host publication13th International Conference on Medical Information Processing and Analysis
EditorsNatasha Lepore, Jorge Brieva, Juan David Garcia, Eduardo Romero
ISBN (Electronic)9781510616332
StatePublished - 2017
Event13th International Conference on Medical Information Processing and Analysis, SIPAIM 2017 - San Andres Island, Colombia
Duration: Oct 5 2017Oct 7 2017

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


Other13th International Conference on Medical Information Processing and Analysis, SIPAIM 2017
CitySan Andres Island


  • Neurocranium
  • brain
  • neonatal/pediatric imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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