Covalent Organic Frameworks for Biomedical Applications

Arezoo Esrafili, Avery Wagner, Sahil Inamdar, Abhinav P. Acharya

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations


Covalent organic frameworks (COFs) are porous organic polymeric materials that are composed of organic elements and linked together by the thermodynamically stable covalent bonds. The applications of COFs in energy sector and drug delivery are afforded because of the desirable properties of COFs, such as high stability, low density, large surface area, multidimensionality, porosity, and high-ordered crystalline structure expanded. In this review COFs are reviewed, from the perspective of different types of reported COFs, different methods for their synthesis, and their potential applications in the biomedical field. The main goal of this review is to introduce COFs as a biomaterial and to identify specific advantages of different types of COFs that can be exploited for specialized biomedical applications, such as immune engineering.

Original languageEnglish (US)
Article number2002090
JournalAdvanced Healthcare Materials
Issue number6
StatePublished - Mar 17 2021


  • COFs
  • biocompatibility
  • biodegradable COFs
  • biomaterials
  • drug delivery

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science


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