TY - JOUR
T1 - Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior
AU - Bobadilla, Ana Clara
AU - Heinsbroek, Jasper A.
AU - Gipson-Reichardt, Cassandra
AU - Griffin, William C.
AU - Fowler, Christie D.
AU - Kenny, Paul J.
AU - Kalivas, Peter W.
PY - 2017
Y1 - 2017
N2 - The idea that interconnected neuronal ensembles code for specific behaviors has been around for decades; however, recent technical improvements allow studying these networks and their causal role in initiating and maintaining behavior. In particular, the role of ensembles in drug-seeking behaviors in the context of addiction is being actively investigated. Concurrent with breakthroughs in quantifying ensembles, research has identified a role for synaptic glutamate spillover during relapse. In particular, the transient relapse-associated changes in glutamatergic synapses on accumbens neurons, as well as in adjacent astroglia and extracellular matrix, are key elements of the synaptic plasticity encoded by drug use and the metaplasticity induced by drug-associated cues that precipitate drug-seeking behaviors. Here, we briefly review the recent discoveries related to ensembles in the addiction field and then endeavor to link these discoveries with drug-induced striatal plasticity and cue-induced metaplasticity toward deeper neurobiological understandings of drug seeking.
AB - The idea that interconnected neuronal ensembles code for specific behaviors has been around for decades; however, recent technical improvements allow studying these networks and their causal role in initiating and maintaining behavior. In particular, the role of ensembles in drug-seeking behaviors in the context of addiction is being actively investigated. Concurrent with breakthroughs in quantifying ensembles, research has identified a role for synaptic glutamate spillover during relapse. In particular, the transient relapse-associated changes in glutamatergic synapses on accumbens neurons, as well as in adjacent astroglia and extracellular matrix, are key elements of the synaptic plasticity encoded by drug use and the metaplasticity induced by drug-associated cues that precipitate drug-seeking behaviors. Here, we briefly review the recent discoveries related to ensembles in the addiction field and then endeavor to link these discoveries with drug-induced striatal plasticity and cue-induced metaplasticity toward deeper neurobiological understandings of drug seeking.
KW - Cocaine self-administration
KW - Cued reinstatement
KW - Glutamate
KW - Neuronal ensembles
KW - Nucleus accumbens
KW - Spines
KW - Synaptic plasticity
KW - Synaptic potentiation
UR - http://www.scopus.com/inward/record.url?scp=85028886467&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028886467&partnerID=8YFLogxK
U2 - 10.1016/bs.pbr.2017.07.013
DO - 10.1016/bs.pbr.2017.07.013
M3 - Article
C2 - 29054293
AN - SCOPUS:85028886467
SN - 0079-6123
JO - Progress in Brain Research
JF - Progress in Brain Research
ER -