@article{7ef92a224893433baaff32555d1a4a3d,
title = "Conformational landscape of a virus by single-particle X-ray scattering",
abstract = "Using a manifold-based analysis of experimental diffraction snapshots from an X-ray free electron laser, we determine the three-dimensional structure and conformational landscape of the PR772 virus to a detector-limited resolution of 9 nm. Our results indicate that a single conformational coordinate controls reorganization of the genome, growth of a tubular structure from a portal vertex and release of the genome. These results demonstrate that single-particle X-ray scattering has the potential to shed light on key biological processes.",
author = "Ahmad Hosseinizadeh and Ghoncheh Mashayekhi and Jeremy Copperman and Peter Schwander and Ali Dashti and Reyhaneh Sepehr and Russell Fung and Marius Schmidt and Yoon, {Chun Hong} and Brenda Hogue and Williams, {Garth J.} and Andrew Aquila and Abbas Ourmazd",
note = "Funding Information: We acknowledge valuable discussions with H. Chapman, E. Lattman, J. Spence and I. Vartaniants. The research conducted at University of Wisconsin–Milwaukee was supported by the US Department of Energy, Office of Science, Basic Energy Sciences, under contract DE-SC0002164 (A.O., algorithm design and development) and by the US National Science Foundation (NSF) under contract STC 1231306 (A.O., numerical trial models and data analysis; M.S., data analysis) and under contract number 1551489 (A.O., underlying analytical models). The research at Arizona State University was supported by the NSF under contract STC 1231306 (B.G.H.). Use of the Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, was supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences under contract DE-AC02-76SF00515. Publisher Copyright: {\textcopyright} 2017 Nature America, Inc., part of Springer Nature. All Rights Reserved.",
year = "2017",
month = aug,
day = "31",
doi = "10.1038/nmeth.4395",
language = "English (US)",
volume = "14",
pages = "877--881",
journal = "Nature Methods",
issn = "1548-7091",
publisher = "Nature Publishing Group",
number = "9",
}