Conductance Titration of Single-Peptide Molecules

Xiaoyin Xiao, Bingqian Xu, Nongjian Tao

Research output: Contribution to journalArticlepeer-review

143 Scopus citations


We have measured the conductance of single peptides covalently bonded to two Au electrodes via S-Au bonds by repeatedly forming a large number of molecular junctions. The conductance decreases exponentially with the peptide length, with a decay constant of β = 0.9 ± 0.1 Å-1, suggesting that tunneling is the mechanism of electron transport in the peptides. The conductance of the peptides is sensitive to the solution pH, due to the protonation/deprotonation of the amine and carboxyl groups of the peptides, which provides titration measurements based on single-molecule conductance.

Original languageEnglish (US)
Pages (from-to)5370-5371
Number of pages2
JournalJournal of the American Chemical Society
Issue number17
StatePublished - May 5 2004

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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