Complications, symptoms, quality of life and pregnancy in cholestatic liver disease

Kais Zakharia, Anilga Tabibian, Keith Lindor, James H. Tabibian

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Cholestatic liver diseases (CLDs) encompass a variety of disorders of bile formation and/or flow which generally result in progressive hepatobiliary injury and ultimately end-stage liver disease. Many patients with CLD are diagnosed between the ages of 20-50 years, a particularly productive period of life professionally, biologically and in other respects; it is not surprising, thus, that CLD is often associated with impaired health-related quality of life (HRQOL) and uncertainty regarding implications for and outcomes of pregnancy. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most prominent CLDs, both having considerable morbidity and mortality and representing major indications for liver transplantation. These disorders, as a consequence of their complications (eg ascites, hepatic osteodystrophy), associated conditions (eg inflammatory bowel disease) and symptoms (eg pruritus and fatigue), can significantly impair an array of domains of HRQOL. Here we review these impactful clinical aspects of PSC and PBC as well as the topics of fertility and pregnancy.

Original languageEnglish (US)
Pages (from-to)399-411
Number of pages13
JournalLiver International
Issue number3
StatePublished - Mar 2018


  • biliary tract diseases
  • pharmacotherapy
  • primary biliary cholangitis
  • primary sclerosing cholangitis
  • pruritus

ASJC Scopus subject areas

  • Hepatology


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