Comparative Genomics of Closely-Related Gordonia Cluster DR Bacteriophages

Cyril J. Versoza, Abigail A. Howell, Tanya Aftab, Madison Blanco, Akarshi Brar, Elaine Chaffee, Nicholas Howell, Willow Leach, Jackelyn Lobatos, Michael Luca, Meghna Maddineni, Ruchira Mirji, Corinne Mitra, Maria Strasser, Saige Munig, Zeel Patel, Minerva So, Makena Sy, Sarah Weiss, Susanne P. Pfeifer

Research output: Contribution to journalArticlepeer-review


Bacteriophages infecting bacteria of the genus Gordonia have increasingly gained interest in the scientific community for their diverse applications in agriculture, biotechnology, and medicine, ranging from biocontrol agents in wastewater management to the treatment of opportunistic pathogens in pulmonary disease patients. However, due to the time and costs associated with experimental isolation and cultivation, host ranges for many bacteriophages remain poorly characterized, hindering a more efficient usage of bacteriophages in these areas. Here, we perform a series of computational genomic inferences to predict the putative host ranges of all Gordonia cluster DR bacteriophages known to date. Our analyses suggest that BiggityBass (as well as several of its close relatives) is likely able to infect host bacteria from a wide range of genera—from Gordonia to Nocardia to Rhodococcus, making it a suitable candidate for future phage therapy and wastewater treatment strategies.

Original languageEnglish (US)
Article number1647
Issue number8
StatePublished - Aug 2022


  • Gordonia
  • bacteriophage
  • cluster DR
  • comparative genomics
  • host range

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


Dive into the research topics of 'Comparative Genomics of Closely-Related Gordonia Cluster DR Bacteriophages'. Together they form a unique fingerprint.

Cite this