Combinatorial self-assembly of DNA nanostructures

Kyle Lund, Yan Liu, Hao Yan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


A modular design of self - assembly of DNA nanostructures in a combinatorial approach is reported. The design and construction of periodic or complex nanostructures using branched DNA building blocks ( DNA tiles ) is being backed by structural DNA nanotechnology. Modular design and reuse of DNA tiles in self-assembly allows the tuning of lattice patterns without modifying the majority of building blocks. The sequences of the sticky-ends were designed to allow for the connection of the tiles in three different patterns namely the square structure, chair structure and line structure. The square structure contains four corner tiles and four linker tiles, chair structure combines the four corner tiles and three linker tiles, and line structure combines the four corner tiles and three linker tiles. The combination of this newly developed technology coupled with several other strategies can open possibilities to assemble more complex superstructures of different building blocks.

Original languageEnglish (US)
Pages (from-to)3402-3403
Number of pages2
JournalOrganic and Biomolecular Chemistry
Issue number18
StatePublished - 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Combinatorial self-assembly of DNA nanostructures'. Together they form a unique fingerprint.

Cite this