Cognition and freezing of gait in Parkinson's disease: A systematic review and meta-analysis

A. S. Monaghan; E. Gordon; L. Graham; E. Hughes; D. S. Peterson; R. Morris

doi:10.1016/j.neubiorev.2023.105068

Cognition and freezing of gait in Parkinson's disease: A systematic review and meta-analysis

A. S. Monaghan, E. Gordon, L. Graham, E. Hughes, D. S. Peterson, R. Morris

Health Solutions, College of (CHS)

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Freezing of gait (FOG) is a common and disabling symptom in people with Parkinson's Disease (PwPD). Although cognition is thought to be worse in PwPD who freeze, a comprehensive analysis of this relationship will inform future research and clinical care. This systematic review and meta-analysis compared cognition between PwPD who do and do not exhibit FOG across a range of cognitive domains and assessed the impact of disease severity and medication status on this relationship. 145 papers (n = 9010 participants) were included in the analysis, with 144 and 138 articles meeting the criteria to assess moderating effects of disease severity and medication status, respectively. PwPD who freeze exhibited worse cognition than PwPD without FOG across global cognition, executive function/attention, language, memory, and visuospatial domains. Greater disease severity and “ON” levodopa medication status moderated the FOG status-cognition relationship in global cognitive performance but not in other cognitive domains. This meta-analysis confirmed that cognition is worse in PwPD with FOG and highlights the importance of disease severity and medication status in this relationship.

Original language	English (US)
Article number	105068
Journal	Neuroscience and Biobehavioral Reviews
Volume	147
DOIs	https://doi.org/10.1016/j.neubiorev.2023.105068
State	Published - Apr 2023

Keywords

Cognition
Cognitive impairment
Freezing of gait
Non-freezers
Parkinson's disease
People with Parkinson's disease

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Behavioral Neuroscience

Access to Document

10.1016/j.neubiorev.2023.105068

Cite this

@article{847ec6b4d10b462895c85c45c37d3bca,

title = "Cognition and freezing of gait in Parkinson's disease: A systematic review and meta-analysis",

abstract = "Freezing of gait (FOG) is a common and disabling symptom in people with Parkinson's Disease (PwPD). Although cognition is thought to be worse in PwPD who freeze, a comprehensive analysis of this relationship will inform future research and clinical care. This systematic review and meta-analysis compared cognition between PwPD who do and do not exhibit FOG across a range of cognitive domains and assessed the impact of disease severity and medication status on this relationship. 145 papers (n = 9010 participants) were included in the analysis, with 144 and 138 articles meeting the criteria to assess moderating effects of disease severity and medication status, respectively. PwPD who freeze exhibited worse cognition than PwPD without FOG across global cognition, executive function/attention, language, memory, and visuospatial domains. Greater disease severity and “ON” levodopa medication status moderated the FOG status-cognition relationship in global cognitive performance but not in other cognitive domains. This meta-analysis confirmed that cognition is worse in PwPD with FOG and highlights the importance of disease severity and medication status in this relationship.",

keywords = "Cognition, Cognitive impairment, Freezing of gait, Non-freezers, Parkinson's disease, People with Parkinson's disease",

author = "Monaghan, {A. S.} and E. Gordon and L. Graham and E. Hughes and Peterson, {D. S.} and R. Morris",

note = "Funding Information: We would like to thank Tea McCormack, Avi Zandieh, and Jordan Barajas for their assistance with data extraction. We would also like to thank all the authors who complied with our request for data. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The authors declare no commercial or financial conflict of interest. Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = apr,

doi = "10.1016/j.neubiorev.2023.105068",

language = "English (US)",

volume = "147",

journal = "Neuroscience and Biobehavioral Reviews",

issn = "0149-7634",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Cognition and freezing of gait in Parkinson's disease

T2 - A systematic review and meta-analysis

AU - Monaghan, A. S.

AU - Gordon, E.

AU - Graham, L.

AU - Hughes, E.

AU - Peterson, D. S.

AU - Morris, R.

N1 - Funding Information: We would like to thank Tea McCormack, Avi Zandieh, and Jordan Barajas for their assistance with data extraction. We would also like to thank all the authors who complied with our request for data. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The authors declare no commercial or financial conflict of interest. Publisher Copyright: © 2023

PY - 2023/4

Y1 - 2023/4

N2 - Freezing of gait (FOG) is a common and disabling symptom in people with Parkinson's Disease (PwPD). Although cognition is thought to be worse in PwPD who freeze, a comprehensive analysis of this relationship will inform future research and clinical care. This systematic review and meta-analysis compared cognition between PwPD who do and do not exhibit FOG across a range of cognitive domains and assessed the impact of disease severity and medication status on this relationship. 145 papers (n = 9010 participants) were included in the analysis, with 144 and 138 articles meeting the criteria to assess moderating effects of disease severity and medication status, respectively. PwPD who freeze exhibited worse cognition than PwPD without FOG across global cognition, executive function/attention, language, memory, and visuospatial domains. Greater disease severity and “ON” levodopa medication status moderated the FOG status-cognition relationship in global cognitive performance but not in other cognitive domains. This meta-analysis confirmed that cognition is worse in PwPD with FOG and highlights the importance of disease severity and medication status in this relationship.

AB - Freezing of gait (FOG) is a common and disabling symptom in people with Parkinson's Disease (PwPD). Although cognition is thought to be worse in PwPD who freeze, a comprehensive analysis of this relationship will inform future research and clinical care. This systematic review and meta-analysis compared cognition between PwPD who do and do not exhibit FOG across a range of cognitive domains and assessed the impact of disease severity and medication status on this relationship. 145 papers (n = 9010 participants) were included in the analysis, with 144 and 138 articles meeting the criteria to assess moderating effects of disease severity and medication status, respectively. PwPD who freeze exhibited worse cognition than PwPD without FOG across global cognition, executive function/attention, language, memory, and visuospatial domains. Greater disease severity and “ON” levodopa medication status moderated the FOG status-cognition relationship in global cognitive performance but not in other cognitive domains. This meta-analysis confirmed that cognition is worse in PwPD with FOG and highlights the importance of disease severity and medication status in this relationship.

KW - Cognition

KW - Cognitive impairment

KW - Freezing of gait

KW - Non-freezers

KW - Parkinson's disease

KW - People with Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=85149333957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85149333957&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2023.105068

DO - 10.1016/j.neubiorev.2023.105068

M3 - Review article

C2 - 36738813

AN - SCOPUS:85149333957

SN - 0149-7634

VL - 147

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

M1 - 105068

ER -

Cognition and freezing of gait in Parkinson's disease: A systematic review and meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this