Abstract
This paper presents a readout and control architecture for single-cell real-time microsystems. The singlecell microsystem comprises 0.35-μm CMOS electronics combined with post-CMOS processing to form a microhotplate and Platinum (Pt) electrodes, and a polymethyl methacrylate (PMMA) microfluidic device to form the microchannel. The on-chip electronics can measure cell parameters such as rate of cell respiration, cell size, membrane capacitance, and cytoplasm resistance. Further, the on-chip electronics can control the microchannel temperature to quantify single-cell messenger RNA (mRNA) for gene expression by quantitative Reverse Transcriptase-Polymerase Chain Reaction (qRTPCR). The chip communication is handled with an I 2C digital standard interface.
Original language | English (US) |
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Title of host publication | Proceedings - IEEE International Symposium on Circuits and Systems |
Pages | 4795-4798 |
Number of pages | 4 |
DOIs | |
State | Published - 2005 |
Externally published | Yes |
Event | IEEE International Symposium on Circuits and Systems 2005, ISCAS 2005 - Kobe, Japan Duration: May 23 2005 → May 26 2005 |
Other
Other | IEEE International Symposium on Circuits and Systems 2005, ISCAS 2005 |
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Country/Territory | Japan |
City | Kobe |
Period | 5/23/05 → 5/26/05 |
ASJC Scopus subject areas
- Electrical and Electronic Engineering