Classification of Breast Masses Using a Computer-Aided Diagnosis Scheme of Contrast Enhanced Digital Mammograms

Gopichandh Danala, Bhavika Patel, Faranak Aghaei, Morteza Heidari, Jing Li, Teresa Wu, Bin Zheng

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Contrast-enhanced digital mammography (CEDM) is a promising imaging modality in breast cancer diagnosis. This study aims to investigate how to optimally develop a computer-aided diagnosis (CAD) scheme of CEDM images to classify breast masses. A CEDM dataset of 111 patients was assembled, which includes 33 benign and 78 malignant cases. Each CEDM includes two types of images namely, low energy (LE) and dual-energy subtracted (DES) images. A CAD scheme was applied to segment mass regions depicting on LE and DES images separately. Optimal segmentation results generated from DES images were also mapped to LE images or vice versa. After computing image features, multilayer perceptron based machine learning classifiers that integrate with a correlation-based feature subset evaluator and leave-one-case-out cross-validation method were built to classify mass regions. When applying CAD to DES and LE images with original segmentation, areas under ROC curves (AUC) were 0.759 ± 0.053 and 0.753 ± 0.047, respectively. After mapping the mass regions optimally segmented on DES images to LE images, AUC significantly increased to 0.848 ± 0.038 (p < 0.01). Study demonstrated that DES images eliminated overlapping effect of dense breast tissue, which helps improve mass segmentation accuracy. The study demonstrated that applying a novel approach to optimally map mass region segmented from DES images to LE images enabled CAD to yield significantly improved performance.

Original languageEnglish (US)
Pages (from-to)1419-1431
Number of pages13
JournalAnnals of Biomedical Engineering
Issue number9
StatePublished - Sep 15 2018


  • Breast cancer diagnosis
  • Classification of breast masses
  • Computer-aided diagnosis (CAD)
  • Contrast-enhanced digital mammography (CEDM)
  • Performance comparison
  • Segmentation of breast mass regions

ASJC Scopus subject areas

  • Biomedical Engineering


Dive into the research topics of 'Classification of Breast Masses Using a Computer-Aided Diagnosis Scheme of Contrast Enhanced Digital Mammograms'. Together they form a unique fingerprint.

Cite this