Circadian disruption, Per3, and human cytokine secretion

Jaclyn Guess, James B. Burch, Kisito Ogoussan, Cheryl A. Armstead, Hongmei Zhang, Sara Wagner, James R. Hebert, Patricia Wood, Shawn D. Youngstedt, Lorne J. Hofseth, Udai P. Singh, Dawen Xie, William L.M. Hrushesky

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergoing a colonoscopy (n = 70). Adjusted mean serum cytokine concentrations (IL-6, TNF-alpha, gamma-INF, IL-1ra, IL-1-beta, VEGF) were compared among patients with high and low scores for fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory II), or sleep disruption (Pittsburgh Sleep Quality Index), or among patients with different Per3 clock gene variants. Poor sleep was associated with elevated VEGF, and fatigue-related reduced activity was associated with elevated TNF-alpha concentrations. Participants with the 4/5 or 5/5 Per3 variable tandem repeat sequence had elevated IL-6 concentrations compared to those with the 4/4 genotype. Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may play a role.

Original languageEnglish (US)
Pages (from-to)329-336
Number of pages8
JournalIntegrative cancer therapies
Issue number4
StatePublished - 2009
Externally publishedYes


  • Circadian rhythm
  • Clock gene
  • Cytokine
  • Inflammation

ASJC Scopus subject areas

  • Oncology
  • Complementary and alternative medicine


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