Cingulate cortex in pre-MCI cognition

Nathalie Sambuchi, Yonas Endale Geda, Bernard François Michel

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations


Studies of Alzheimer's disease over the years have focused on the prodromal stage, or mild cognitive impairment (MCI), in order to understand its evolution and to diagnose this pathology early. More recently, research has focused on an even earlier stage (pre-MCI) characterized in particular by a cognitive complaint. The purpose of this chapter is, first, to describe the different concepts defining pre-MCI, which refers to cognitive or memory complaint, and to define this concept based on biologic markers (abnormal proteins and neuroimaging). In the second part of the chapter, we describe the cognitive performance of these subjects (pre-MCI), and, finally, in the third part we describe the correlations linking cognitive performance of pre-MCI subjects to cingulate cortex, cingulate gyrus, and cingulum bundle.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Neurology
PublisherElsevier B.V.
Number of pages15
StatePublished - 2019
Externally publishedYes

Publication series

NameHandbook of Clinical Neurology
ISSN (Print)0072-9752
ISSN (Electronic)2212-4152


  • Cingulate gyrus
  • Cingulum bundle
  • Cognition
  • DTI
  • MRI
  • Pre-MCI

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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