Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β

Jing Zhen Deng; A. Sun Di-An; Shelley R. Starck; Sidney M. Hecht; Ronald L. Cerny; John R. Engen

doi:10.1039/a901123d

Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β

Jing Zhen Deng, A. Sun Di-An, Shelley R. Starck, Sidney M. Hecht, Ronald L. Cerny, John R. Engen

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Chrysochlamic acid (1), a new DNA polymerase β inhibitor having an IC₅₀ of 4.3 μM, has been isolated from Chrysochlamys ulei through bioassay-guided fractionation; it is the first example of a prenyl /n-methylhydroquinone occurring in a higher terrestrial plant.

Original language	English (US)
Pages (from-to)	1147-1149
Number of pages	3
Journal	Journal of the Chemical Society - Perkin Transactions 1
Issue number	9
DOIs	https://doi.org/10.1039/a901123d
State	Published - 1999
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

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10.1039/a901123d

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title = "Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β",

abstract = "Chrysochlamic acid (1), a new DNA polymerase β inhibitor having an IC50 of 4.3 μM, has been isolated from Chrysochlamys ulei through bioassay-guided fractionation; it is the first example of a prenyl /n-methylhydroquinone occurring in a higher terrestrial plant.",

author = "Deng, {Jing Zhen} and {Sun Di-An}, A. and Starck, {Shelley R.} and Hecht, {Sidney M.} and Cerny, {Ronald L.} and Engen, {John R.}",

year = "1999",

doi = "10.1039/a901123d",

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AU - Deng, Jing Zhen

AU - Sun Di-An, A.

AU - Starck, Shelley R.

AU - Hecht, Sidney M.

AU - Cerny, Ronald L.

AU - Engen, John R.

PY - 1999

Y1 - 1999

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AB - Chrysochlamic acid (1), a new DNA polymerase β inhibitor having an IC50 of 4.3 μM, has been isolated from Chrysochlamys ulei through bioassay-guided fractionation; it is the first example of a prenyl /n-methylhydroquinone occurring in a higher terrestrial plant.

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Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β

Abstract

ASJC Scopus subject areas

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