Chemical derivatization of therapeutic proteins

Richard A.G. Smith, Janet M. Dewdney, Robin Fears, George Poste

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Despite major advances in redesigning and producing proteins through recombinant DNA technology, many therapeutic proteins are still produced by extraction from biological tissues or fluids, or from nonrecombinant microorganisms. Modification of such proteins, to improve potency and bioavailability and reduce immunogenicity, can only be carried out post-translationally by chemical-derivatization methods. Genetic- and chemical-modification methods are not mutually exclusive, however, and may be combined to optimize protein-engineering strategies, because chemical modification can introduce structural changes that are not encoded by DNA into both recombinant, and nonrecombinant proteins.

Original languageEnglish (US)
Pages (from-to)397-403
Number of pages7
JournalTrends in Biotechnology
Issue number9
StatePublished - Sep 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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