Abstract
cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified Mboll and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.
Original language | English (US) |
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Pages (from-to) | 407-410 |
Number of pages | 4 |
Journal | Human Molecular Genetics |
Volume | 1 |
Issue number | 6 |
DOIs | |
State | Published - Sep 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Genetics(clinical)