Characterization of brain samples in studies of aging, Alzheimer's, and other neurodegenerative diseases

Robert W. Hamill, William R. Markesbery, Keith McDaniel, Paul D. Coleman

Research output: Contribution to journalComment/debatepeer-review

9 Scopus citations


We review current understanding of the clinical and pathologic information needed for the determination of optimal brain tissue samples for the conduct of studies of Alzheimer's disease (AD). Characteristics that may distinguish AD from other dementing disorders are discussed. Selected considerations in the conduct of basic neurobiological studies are also outlined. Although the 28 NIA-funded Alzheimer's Centers can provide excellent clinical and neuropathological data, studies conducted outside these centers should also strive to gather the information suggested here. Clinical and neuropathological data should be used not only to classify subjects as control or AD, but also as variables that may significantly contribute to the analysis of neurobiological data obtained in the laboratory.

Original languageEnglish (US)
Pages (from-to)539-545
Number of pages7
JournalNeurobiology of Aging
Issue number6
StatePublished - 1993
Externally publishedYes


  • Alzheimer's disease
  • Brain samples
  • Diagnosis
  • Neuropathology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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