Celiac vagotomy reduces suppression of feeding by jejunal fatty acid infusions

James E. Cox, William J. Tyler, Alan Randich, Gary R. Kelm, Stephen T. Meller

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


We investigated the role of the celiac branch of the vagus nerve in suppression of food intake produced by jejunal fatty acids infusions. Following selective celiac vagotomy or sham surgery, adult, male Sprague-Dawley rats received 7 h infusions of linoleic acid or saline through indwelling jejunal catheters on four consecutive days. Although linoleic acid still produced significant suppression of intake in rats with celiac vagotomy, it was less effective in these animals than in controls. The temporal pattern of results suggested that celiac afferent fibers are involved in mediating both pre- and postabsorptive effects of infused fatty acids.

Original languageEnglish (US)
Pages (from-to)1093-1096
Number of pages4
Issue number6
StatePublished - May 8 2001
Externally publishedYes


  • Linoleic acid
  • Rats
  • Satiety
  • Small intestine
  • Vagal afferents

ASJC Scopus subject areas

  • General Neuroscience


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