Catch and release: Photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery

Matthew D. Green; Abbygail A. Foster; Chad T. Greco; Raghunath Roy; Rachel M. Lehr; Thomas H. Epps; Millicent O. Sullivan

doi:10.1039/c4py00638k

Catch and release: Photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery

Matthew D. Green, Abbygail A. Foster, Chad T. Greco, Raghunath Roy, Rachel M. Lehr, Thomas H. Epps, Millicent O. Sullivan

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Binding interactions between DNA and cationic nanocarriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to improved non-viral gene packaging.

Original language	English (US)
Pages (from-to)	5535-5541
Number of pages	7
Journal	Polymer Chemistry
Volume	5
Issue number	19
DOIs	https://doi.org/10.1039/c4py00638k
State	Published - 2014
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Biochemistry
Polymers and Plastics
Organic Chemistry

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title = "Catch and release: Photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery",

abstract = "Binding interactions between DNA and cationic nanocarriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to improved non-viral gene packaging.",

author = "Green, {Matthew D.} and Foster, {Abbygail A.} and Greco, {Chad T.} and Raghunath Roy and Lehr, {Rachel M.} and Epps, {Thomas H.} and Sullivan, {Millicent O.}",

year = "2014",

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T2 - Photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery

AU - Green, Matthew D.

AU - Foster, Abbygail A.

AU - Greco, Chad T.

AU - Roy, Raghunath

AU - Lehr, Rachel M.

AU - Epps, Thomas H.

AU - Sullivan, Millicent O.

PY - 2014

Y1 - 2014

N2 - Binding interactions between DNA and cationic nanocarriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to improved non-viral gene packaging.

AB - Binding interactions between DNA and cationic nanocarriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to improved non-viral gene packaging.

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U2 - 10.1039/c4py00638k

DO - 10.1039/c4py00638k

M3 - Article

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JO - Polymer Chemistry

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Catch and release: Photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery

Abstract

ASJC Scopus subject areas

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